clonazepam cause seizureclonazepam cause seizure

Journal of the American Geriatrics Society. A boxed warning is the most serious warning from the FDA. See also Drug Interactions section. However, you should not flush this medication down the toilet. It is also used to treat panic disorder. All rights reserved. Possibly. 83% of reviewers reported a positive experience, while 9% reported a negative experience. You should also tell your doctor if you have a history of drug misuse or addiction. Clonazepam: a medicine to treat seizures and panic disorder It is also used to treat panic disorder. Properly discard this product when it is expired or no longer needed. Click here for an email preview. It is thought that benzodiazepines work by enhancing the activity of certain neurotransmitters in the brain. Older adults (ages 65 years and older) taking clonazepam usually experience side effects similar to those in younger people taking the drug. the unsubscribe link in the e-mail. [21], Hypersensitivity to drug or components of the formulation. You should always consult your doctor or another healthcare professional before taking any medication. Some dosage forms listed on this page may not apply to the brand name Klonopin. The adverse effectsof clonazepam derive from its property to act as a central nervous system depressant likeall the other BZD drugs. However, animal studies dont always indicate what may happen in humans. Examples of withdrawal symptoms may include: You may be at an increased risk of withdrawal and dependence if you take clonazepam for a long time or at a high dose. Klonopin is used to treat certain seizure disorders (including absence seizures or Lennox-Gastaut syndrome) in adults and children. Clonazepam tablets can cause abuse and dependence. Its possible for clonazepam to cause breathing problems. Withdrawal symptoms can start after you stop treatment with clonazepam. Most side effects of clonazepam are short term. If youre an older adult taking clonazepam and have questions or concerns about side effects, talk with your doctor or pharmacist. The Journal of clinical psychiatry. This condition happens when changing positions, such as standing up quickly. Talk to your doctor if you are using marijuana (cannabis). Filter by condition. include protected health information. Older adults and children are especially prone to the adverse effects of clonazepam due to impaired or immature liver function. Older adults usually start with a lower dose to decrease the risk of side effects. In patients with absence seizures (petit mal) who have failed to respond to succinimides, clonazepam may be useful. However, sometimes the drug can cause a child to be more energetic than usual. Taking a higher dose of a drug means that more medication is present in your body. Journal of psychiatry & neuroscience : JPN. Instead, use dry hands to peel back the foil packaging. For panic disorder, your doctor may have you take clonazepam for a short time. Klonopin Side Effects Generic name: clonazepam Medically reviewed by Drugs.com. Users. other information we have about you. Clinicians also use it forthe acute treatment of panic attacks. BZDs are a class of psychoactive drugs known for their depressant effect on the central nervous system (CNS). The use of flumazenil, a competitive benzodiazepine receptor antagonist, as the antidote is controversial as its use correlates with lowered seizure threshold and widened QRS complex resulting in adverse effects. Your doctor may adjust your dose as needed. [46], The use of illicit benzodiazepines in combination with opioids is increasing, leading to synergistic toxicity and increased mortality. This should decrease your risk of developing withdrawal symptoms. People may experience travel anxiety due to an anxiety disorder or negative past experiences. Open the pouch and peel back the foil layer. Klonopin's mild side effects include: drowsiness. [17][24], Clonazepam can causeblurred vision, confusion, irritability, loss of libido, lack of motivation, psychomotor agitation, hallucination, worsening of depression, short-term memory loss, and anterograde amnesia, especially with high doses. Paxlovid(TM) Information From FDA and Guidance for AES Members. It has links with some facial and cardiac malformations of the human fetus. Click here for more links and local resources. Benzodiazepines facilitate GABA-A action by increasing the frequency of chloride channel opening resulting in hyperpolarization of the neurons and reduced firing, thus producing calming effects on the brain by decreasing the excitability of neurons. Clonazepam is also used to treat symptoms of akathisia (restlessness and a need for constant movement) that may occur as a side effect of treatment with antipsychotic medications (medications for mental illness) and to treat acute catatonic reactions (state in which a person does not move or speak at all or moves or speaks abnormally). Clonazepam may be habit forming. The use of clonazepam is most commonly associated with lethargy, fatigue, sedation, drowsiness, and motor impairment (impaired coordination, impaired balance, dizziness). This can increase your risk of side effects. problems with . [49][Level 5], Chouinard G, Labonte A, Fontaine R, Annable L. New concepts in benzodiazepine therapy: rebound anxiety and new indications for the more potent benzodiazepines. About clonazepam Who can and cannot take it How and when to take it Side effects Pregnancy, breastfeeding and fertility . Prescribed Benzodiazepines and Suicide Risk: A Review of the Literature. Ask your pharmacist about using those products safely. [8], Clonazepam has anticonvulsant and serotonin agonist activity, both of which are associated with its antimanic effect. Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine). Medicine. This drug may make you dizzy or drowsy. Your doctor will order certain lab tests to check your response to clonazepam. Children up to 10 years or 30 kilograms (kg) of body weightDose is based on body . Sleep-Related Eating Disorder (SRED): Paradoxical Effect of Clonazepam. Get in touch with us via one of these free and confidential options. Once ordered by the clinicians, nursesoften administer the drug. Behavioral interventions to help you change your thoughts, emotions, and behaviors surrounding your substance use. doi: 10.1097/MD.0000000000002881. Weight gain and weight loss were reported in people taking clonazepam for seizure disorders, but this was not common. Each receptor complex has 2 GABA-binding sites and 1 BZD-binding site andiscomprisedof five subunits: two alpha, two beta, and one gamma. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). Older adults (ages 65 years and older) taking clonazepam may have a higher risk of side effects than younger people taking the drug. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Its important to note that clonazepam is broken down and removed from the body by the kidneys and liver. Clonazepam overdose typically presents as oversedation with symptoms that may include:6, Oversedation is typically not life threatening and can often be reversed with flumazenil, a prescription drug.6, However, mixing drugs (polysubstance use)specifically combining clonazepam with opioids, alcohol, and other CNS depressantscan lead to life-threatening respiratory depression, slowed or stopped breathing, and can be fatal.6, Between 2019 and 2020, the Centers for Disease Control and Prevention (CDC) found that over 90% of all benzodiazepine-involved overdose deaths also involved prescription or illicitly manufactured opioids, based on data collected from 23 states.8, Studies indicate that the use of clonazepam during pregnancy may cause temporary withdrawal symptoms in some newbornswhich may include trouble breathing, poor circulation, and low muscle toneespecially when the baby is exposed to clonazepam at the end of the pregnancy.9, Two studies suggest that babies exposed to clonazepam during pregnancy might be more likely to be born preterm or with low birth weight. [14][15], Clonazepam is a highly potent long-acting benzodiazepine. Any level over 0.08 mcg/mL is considered toxic. Epub 2022 Apr 4 [PubMed PMID: 36451851], Razeghinejad MR, Pro MJ, Katz LJ. privacy practices. Check with your doctor immediately if any of the following side effects . Referring to the following articles about clonazepam and Klonopin can provide you with additional information: Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. A prescription drug monitoring program (PDMP) can identify potential misuse.[44]. Clonazepam may harm the fetus. Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine. They can recommend the right dose of clonazepam for you. Clonazepam is available as an immediate-release tablet of 0.5 mg, 1 mg, 2 mg, and orally disintegrated tablets (ODT) of 0.125 mg, 0.25 mg,0.5 mg, 1 mg, and 2 mg strength. Addiction is when you need to take a drug to feel as you usually do, even if it negatively affects your life. For children, the long-term effects on physical and mental/behavioral development are uncertain and may not be seen until after many years. [16], GABA is an inhibitory neurotransmitter in abundance in the cortex and limbic system. Take exactly as directed by your doctor. Low blood pressure was reported rarely in people taking clonazepam for panic disorder. Older adults should receive low doses of clonazepam because higher doses may not work better and may cause serious side effects. Here are some frequently asked questions about the drugs side effects and their answers. information and will only use or disclose that information as set forth in our notice of 2021 Jun:13(6):e15816. Do not stop taking clonazepam tablets all of a sudden. In the US - Call your doctor for medical advice about side effects. (2022). 2013:23 Suppl 1():17-26 [PubMed PMID: 24672891], Perucca E. Clinically relevant drug interactions with antiepileptic drugs. Concurrent use of benzodiazepines and opioids may result in sedation, respiratory depression, coma, and death. Clinical and experimental neurology. Stopping clonazepam suddenly can worsen your condition and cause withdrawal symptoms that may last for several weeks to more than 12 months. Clonazepam is a long-acting and high-potency benzodiazepine; it behaves as a GABA-A . Clonazepam works by calming . Use of the term female in this article refers to sex assigned at birth. 2022 Feb:42(2):128-161. doi: 10.1177/03331024211036152. Long-term use also leads to developing tolerance, especially to its anticonvulsant properties, which can precipitate a seizure. Seizure Disorders: Klonopin is useful alone or as an adjunct in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic, and myoclonic seizures. 5. Epub 2012 Oct 4 [PubMed PMID: 23038269], Griffin CE 3rd, Kaye AM, Bueno FR, Kaye AD. Clonazepam is contraindicated in severe liver disease. Both clonazepam and opioids can cause a condition called central nervous system (CNS) depression. [3]Acombination of benzodiazepine and the antipsychotic haloperidol is considered the most effective treatment of acute agitation in the emergency department. Withdrawal symptoms may begin within hours of the drug leaving your system and may come and go at times. Duplication for commercial use must be authorized by ASHP. Keep in mind that your kidneys remove clonazepam from your body. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. 2006 Sep-Oct:19(5):435-41 [PubMed PMID: 17323720], Aurora RN, Zak RS, Maganti RK, Auerbach SH, Casey KR, Chowdhuri S, Karippot A, Ramar K, Kristo DA, Morgenthaler TI, Standards of Practice Committee, American Academy of Sleep Medicine. Withdrawal symptoms may sometimes last weeks to months. Talk to your pharmacist for more details. Uses. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Neuropsychiatric disease and treatment. Clonazepam is used to treat certain seizure disorders (including absence seizures or Lennox-Gastaut syndrome) in adults and children. In addition, they may be able to recommend ways to manage your weight, such as with physical activity or diet. These issues can result in poor patient outcomes from drug dependence, misuse, abuse, motor impairment, etc. Misusing a drug means taking it in a way thats different than how your doctor prescribed it. Clonazepam's major metabolite, 7-amino-clonazepam, is excreted mainly in the urine. Following administration in hospital settings, its use may carry over to primary care without any indication; this is where a pharmacist performing medication reconciliation on discharge is invaluable. Allergic reaction. All Rights Reserved. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). They can last for weeks or months after your treatment ends. The dosage may be increased by 0.5 to 1 mg every three days until seizures are under control. Clonazepam is used short term in adults to treat symptoms of panic disorder, including panic attacks. However, if your symptoms are serious and you think youre having a medical emergency, immediately call 911 or your local emergency number. Summary of Anti-Seizure Medications Clonazepam is used alone or together with other medicines to treat certain seizure disorders (eg, Lennox-Gastaut syndrome, akinetic, myoclonic, and absence seizures). Topical clonazepam for burning mouth syndrome: Is it efficacious in patients with anxiety or depression? This survey is being conducted by the WebMD marketing sciences department. If you have questions about alcohol and clonazepam, talk with your doctor. Clonazepam (Klonopin) is a generic prescription medication. They can help determine whether clonazepam is a safe treatment option. Coping skills training to help you identify triggers, manage stressors, and prevent relapse. Clonazepam may worsen symptoms of a genetic condition called porphyria. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. 2022 Jan:49(1):54-61. doi: 10.1111/joor.13275. Clonazepam is a controlled substance. Hypersensitivity to clonazepam is rare, but there are occasional reports. Panic attacks and anxiety attacks share some symptoms, but they differ in intensity, duration, and whether or not there is a trigger. Before starting treatment with clonazepam, talk with your doctor about any medical conditions that you have. Older patients are especially prone to this side effect. Tell your doctor if your condition lasts or gets worse. Do not try to push the orally disintegrating tablet through the foil. Do not stop taking clonazepam all of a sudden. What should I know about storage and disposal of this medication? To learn more, see Clonazepam: Side effect specifics above. Keep this medication in the container it came in, tightly closed, and out of reach of children. You can also ask them about Klonopin, the brand-name version of clonazepam. Clonazepam may cause side effects such as loss of coordination and drowsiness. For a general overview of clonazepam, including details about its uses, refer to this article. 2004 Mar:78(3):201-8 [PubMed PMID: 15013244], . Epub [PubMed PMID: 33625005], Singh D, Narayanan S, Grundmann O, Boyer EW, Vicknasingam B. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. . However, it is not used as first-line therapy for these conditions. Psychopharmacology in Pregnancy and Breastfeeding. doi: 10.4088/PCC.16r02037. It has no role in multidrug toxicity and should only be used following a consultation with a medical toxicologist. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Copyright, 2023. However, its unknown what effects this may have on a breastfed child. Myoclonic jerks may occur in the following scenarios: Your doctor may tell you not to take clonazepam. Mayo Clinic does not endorse companies or products. Your dose may need to be gradually decreased. Tell your doctor right away if you or your family/caregiver notice any unusual/sudden changes in your mood, thoughts, or behavior, including: confusion, memory problems, signs of depression, suicidal thoughts/attempts, thoughts about harming yourself. Medications and other treatments may help reduce their frequency and severity. Epub 2019 Jan 29 [PubMed PMID: 30693946], Stacy M. Sleep disorders in Parkinson's disease: epidemiology and management. AHFS Patient Medication Information. Panic attacks can be sudden and overpowering. Clinical pharmacology and therapeutics. Epilepsy research. Klonopin side effects: What they are and how to manage them The supportive care includes monitoring vitals, IV fluids for hypotension, atropine for bradycardia, and maintaining the patency of the airway by intubation or artificial respiration if respiratory depression develops. Klonopin, and brand name for clonazepam, is a benzodiazepine that medical practitioners prescribe for the short-term treatment of panic disorder and certain types of seizure disorders. MMWR. Clonazepam (Klonopin) - Side Effects, Interactions, Uses, Dosage, Warnings It is also used to treat panic attacks. 1987 Nov-Dec:1(6):347-56 [PubMed PMID: 3504409], Dodds TJ. User Reviews for Clonazepam for Seizure Prevention. Because of this, your doctor will usually prescribe the lowest possible dose of clonazepam for you. Drug information provided by: Merative, Micromedex. * Sex and gender exist on spectrums. Distribution: Clonazepam is approximately 85% bound to plasma proteins. So, your doctor may prescribe a lower dose of clonazepam if you have a kidney problem. Clonazepam is usually started after an acute event or during the hospital stay by the clinicians. * For more information about this side effect, see Clonazepam: Side effect specifics below. Do not double the dose to catch up. The use ofclonazepamalong with kratom may lead to increased CNS depression and death. In Canada - Call your doctor for medical advice about side effects. The Psychiatric clinics of North America. If we combine this information with your protected These side effects can increase the risk of falling. Supportive care and medical observation are the mainstays of the treatment. Cephalalgia : an international journal of headache. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). 2021 Mar 4:21(1):125. doi: 10.1186/s12888-021-03132-2. Clonazepam (Klonopin), a tranquilizer, is the most common drug used to treat myoclonus symptoms. Clonazepam: a review of its pharmacological properties and therapeutic efficacy in epilepsy. If you, friends, family, or a caregiver notice that you have any of these symptoms, your doctor should be consulted right away. If you are a Mayo Clinic patient, this could If the drug is the cause, your doctor may lower your dose. British journal of clinical pharmacology. Clonazepam is a DEA-schedule IV drug. 1994 Nov-Dec:8(6):461-75 [PubMed PMID: 7881198], Payne JL. [36]Paradoxical sleep-related eating disorder (SRED) has been described, although clonazepam is used to treat SRED. The Ochsner journal. 1976 Nov:12(5):321-61 [PubMed PMID: 976134], Marchesi C. Pharmacological management of panic disorder. Due to its potential effectforinducing CNS depression, clonazepam may impair judgment, thinking, and motor skills. Drugs used to control epileptic seizures may help reduce myoclonus symptoms. They should improve or go away throughout your treatment or after stopping treatment. Clonazepam may be used as part of a combination therapy. Keep all appointments with your doctor and the laboratory. Epub 2021 Aug 18 [PubMed PMID: 34404247], Rossella I, Alessandro V, Naman R, Gary K, Herv SY. Older adults may be more sensitive to the effects of this drug, especially drowsiness and confusion. The continued useof clonazepamcanlead to physical dependence. Treatment should start at a dose of 0.25 mg tablets, taken twice a day orally for three days, after which the dose should be increased to 0.5 mg tablets twice daily. If you take clonazepam and an opioid, your risk of CNS depression increases. Myoclonus - Diagnosis and treatment Long-Term Use of Klonopin and Risk of Severe Addiction, Klonopin Addiction: Symptoms and Signs of Abuse. This can increase your risk of side effects. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Consult your doctor right away if this happens. The maximum daily dose should not exceed 1to 4 mg. Therefore, an interprofessional approach is required to develop ideas to reduce the use of hypnotics and develop interventions to prevent misuse in the hospital and at the primary and secondary care interface. [19], Liver Impairment and/or Renal Impairment:No dosage adjustment information is given in the manufacturer's labeling; use it with caution. Notes from the Field: Illicit Benzodiazepines Detected in Patients Evaluated in Emergency Departments for Suspected Opioid Overdose - Four States, October 6, 2020-March 9, 2021. Review/update the Then your doctor can slowly increase your dose until the right level is reached. information submitted for this request. Along with its needed effects, a medicine may cause some unwanted effects. Withdrawal symptoms include anxiety, irritability, insomnia, tremors, headache, depression, sweating, confusion, hallucinations, and seizures. Why Parkinson's research is zooming in on the gut. Clonazepam Oral: Uses, Side Effects, Interactions, Pictures - WebMD Your doctor can tell you more. Glaucoma. Klonopin is. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Consequently, increasing awareness among providers, patient education, and community involvement regarding hazards associated with illicit benzodiazepines is crucial.[47][48]. 2005 Jan:18(1):45-50 [PubMed PMID: 16639183], Chouinard G. The search for new off-label indications for antidepressant, antianxiety, antipsychotic and anticonvulsant drugs. Community mental health journal. Its possible to develop dependence on a drug even if you take it exactly as your doctor prescribes. WebMD does not provide medical advice, diagnosis or treatment. However, use may be justified for seizure disorders and severe generalized anxiety disorder.[23]. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Clonazepam can cause certain side effects (also called adverse effects). If breastfeeding or considering it, talk with your doctor before taking clonazepam. However, since untreated seizures are a serious condition that can harm both a pregnant woman and her unborn baby, do not stop taking this medication unless directed by your doctor. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions. Your doctor may need to change the dosages of your medications and will monitor you carefully. To sign up for the registry, call 888-233-2334 or visit its website. Porphyria. In fact, the drug has a boxed warning for this risk. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. Although not all of these side effects may occur, if they do occur they may need medical attention. 1996 Jan-Feb:16(1):49-57 [PubMed PMID: 8700792], . Myoclonus refers to sudden, brief involuntary twitching or jerking of a muscle or group of muscles. With a panic attack, you have sudden, intense feelings of fear or discomfort.. Postgraduate medicine. Pharmacological interactions and their impact on cerebral function. This means that a child who is breastfed will be exposed to the medication. you should know that your mental health may change in unexpected ways, and you may become suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are taking clonazepam for the treatment of epilepsy, mental illness, or other conditions. Clonazepam Find out how clonazepam treats epileptic seizures or fits, muscle spasms, panic disorder and restless legs syndrome, and how to take it. fatigue. Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. In this case, they may monitor you more frequently than usual while you take clonazepam. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. Myoclonus Clinical EEG (electroencephalography). Impaired GABA neuronal response to acute benzodiazepine administration in panic disorder. Liver problems. Comparison of various treatments for sleep bruxism using determinants of number needed to treat and effect size. tell your doctor what herbal products you are taking, especially St. John's wort. [7]Clonazepam is also useful in treating psychomotor, myoclonic epilepsies,grand mal, and focal motor seizures. 2021 Mar 1:121(3):22-23. doi: 10.1097/01.NAJ.0000737284.82549.8f. MISUSE OF CLONAZEPAM CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Clonazepam 0.5mg Tablets Treatment, Therapy and Management of Metabolic Epilepsy: A Systematic Your doctor may need to add or adjust the dose of your other medications to control the seizures. Coordinate the management of a patient with clonazepam toxicity. However, the data are equivocal. Animal studies showed that congenital anomalies (commonly known as birth defects) occurred when the fetus was exposed to clonazepam. Sporanox) and ketoconazole (Nizoral); antihistamines; certain calcium channel blockers such as diltiazem (Cardizem, Tiazac, others) and verapamil (Calan, Covera, Verelan, in Tarka); cimetidine (Tagamet); HIV protease inhibitors including indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); medications for anxiety, colds or allergies, or mental illness; other medications for seizures such as carbamazepine (Epitol, Tegretol, Teril), phenobarbital, phenytoin (Dilantin, Phenytek), or valproic acid (Depakene); muscle relaxants; nefazodone; rifampin (Rifadin, Rimactane); sedatives; certain selective serotonin reuptake inhibitors (SSRIs) such as fluvoxamine (Luvox); other sleeping pills; and tranquilizers. Lauren Fawley received her Masters Degree in Community Counseling from Arizona State University in 2009 and has since been actively practicing therap . 1977 Apr:21(4):497-514 [PubMed PMID: 14802], Thomson JS, Donald C, Lewin K. Use of Flumazenil in benzodiazepine overdose. In some cases, clonazepam can cause depression or other mood changes. Clonazepam is FDA-approved for use in children to treat seizure disorders, but not for anxiety disorders or other psychiatric problems. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). 2023 Healthline Media UK Ltd, Brighton, UK. For more information, you can refer to clonazepams prescribing information. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. The drug also has many off-label indications, including restless leg syndrome, acute mania, insomnia, and tardive dyskinesia. Clonazepam causes a significant improvement in patients who have panic disorders with or without agoraphobia. KLONOPIN can cause serious side effects, including: KLONOPIN can slow your thinking and motor skills Do not drive, operate heavy. Treatment What is the most important information I should know about Klonopin withdrawal? Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Interventions to decrease the inappropriate use of clonazepam involve an interprofessional team that includes clinicians, nurses, pharmacists, and primary care providers. 2013 Summer:13(2):214-23 [PubMed PMID: 23789008], Kacirova I, Grundmann M, Silhan P, Brozmanova H. A Case Report of Clonazepam Dependence: Utilization of Therapeutic Drug Monitoring During Withdrawal Period. Clonazepam - CURE Epilepsy Pediatric patients (weight < 30 kg): Initially, for pediatric patients, 0.01 to 0.03 mg/kg/day orally(not to exceed 0.05 mg/kg/day)divided into two or three doses is recommended.